Irene is a name derived from the Greek word εἰρήνη (Eirini), "peace".
It may refer to:
- Eirene (Greek goddess), one of the Horae
- Eirene (artist), ancient Greek artist
- Tzitzak (died 750), wife of Emperor Constantine V, who was baptized as Irene
- Byzantine Empress Irene (c. 752–803), wife of Emperor Leo IV and empress regnant, 797–802
- One of several people called Saint Irene, including:
- Irene of Rome (died c. 288)
- Irene of Tomar (died c. 653)
- Irene Castle (1893–1969), half of the early 20th-century ballroom dancing team of Vernon and Irene Castle
- Irene Dunne (1898–1990), Academy-award nominated actress
- Irini Georgatou, Greek tennis player
- Irini Giannatou, birth name of Greek actress and singer Rena Dor
- Eirini Kavarnou, Greek swimmer
- Irene Lentz (1900–1962), American clothing designer in Los Angeles; costume designer for films in the 1930s
- Irini Merkouri, Greek pop singer
- Irini Psyhrami, Greek pop singer
- Irene Ryan (1902–1973), American actress; Granny on The Beverly Hillbillies television show in the 1960s
- Irene Papas (born 1926 or 1929), Greek actress
- Princess Irene of the Netherlands (born 1939), sister of Queen Beatrix of the Netherlands
- Irene Piotrowski (born 1941), Lithuanian-Canadian athlete
- Eirini Sevastou, Greek pop singer
- Irini Terzoglou, Greek shot putter
- Irene Cara (born 1959), American singer, Academy Award–winning songwriter and actress
- Irene de Kok (born 1963), Dutch judoka
- Irene Eijs (born 1966), Dutch rower
- Irene Jacob (born 1966), French-born Swiss actress
- Irene Bedard (born 1967), Native American actress best known for her portrayal of Native American characters
- Irene Saez (born 1961), Venezuelan politician and former Miss Universe
- Irene van Dyk (born 1972), goal shooter for the New Zealand netball team, the Silver Ferns
- Irini Karra, a Greek fashion model
- Irene Galace a program coordinator at Northwestern University.
- Irene, Gauteng, a small town in South Africa
- Irene, Texas, USA, an unincorporated community
- Lake Irene, a small lake in Rocky Mountain National Park, Colorado, USA
- Eirini station, an ISAP metro station in Ano Maroussi, Greece
- Tropical Storm Irene, the name of several of tropical storms
- 14 Irene, an asteroid
- Irene, the hydrocarbon C13 H18 formed by dehydration of Irone
- Irene, South Dakota, a city in South Dakota, USA
- Irene (play), a play by Samuel Johnson
- Irene (musical), a Broadway musical that was first produced in 1919
- Irene (1926 film), 1926 film starring Colleen Moore
- Irene (1940 film), a 1940 Oscar-nominated film starring Anna Neagle and Ray Milland
- Irene (2009 film), a 2009 French film
- Irène (2002 film) a film by Ivan Calberac starring Cécile de France and Bruno Putzulu
- "Goodnight, Irene", a 20th century American folk music standard
- "Irene", a song on Momentum (album) by Christian rapper/singer tobyMac
- Irene (novel), a 1949 novel by Ronald James Marsh
- Irene (band), a 10-member musical group from Sweden
- Irene Redfield, fictional character in the novel Passing by Nella Larsen
- Irene Forsyte, fictional character in The Forsyte Saga
- Irene Adler, fictional character in the Sherlock Holmes story "A Scandal in Bohemia"
- Irene Pollock, fictional character in the 44 Scotland Street series by Alexander McCall Smith
- Irene, a character in the operas Tamerlano and Bajazet, by Handel and Vivaldi.
MV Eirini, a British refrigerated cargo liner in service 1961-70
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